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目的：观察对乙酰氨基酚对肝细胞损伤的影响及阿魏酸钠的保护作用。方法：采用原代肝细胞培养，以细胞存活率及培养液中谷丙转氨酶（ＡＬＴ）活性的变化为指标。结果：对乙酰氨基酚２μｇ·ｍｌ－１与细胞共同培养３ｈ可形成稳定损伤，阿魏酸钠可明显提高损伤肝细胞活率，降低ＡＬＴ活性。结论：阿魏酸钠对肝损伤有保护作用。
Objective: To observe the effect of acetaminophen on hepatocellular injury and the protective effect of sodium ferulate. Methods: Primary hepatocytes were cultured and the changes of cell viability and ALT activity in the culture medium were taken as indexes. Results: Paracetamol 2μg · ml-1 co-cultured with cells for 3h to form a stable injury, sodium ferulate can significantly increase liver cell viability and reduce ALT activity. Conclusion: Sodium ferulate has a protective effect on liver injury.