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21例维持性血液透析(MHD)病人,在透析治疗的同时,加用黄芪注射液治疗,3个月后患者的免疫功能获得明显改善。与正常人相比,MHD患者外周血CD8T细胞、血清sIL-2R水平、血清TNF含量均明显升高;而外周血中CD4/CD8比值和淋巴细胞mIL-2R阳性细胞数明显下降,显示MHD患者的细胞免疫功能降低。经黄芪注射液治疗3个月后,患者外周血CD4T细胞、CD4/CD8比值明显升高,CD8T细胞下降至正常人水平,CD4/CD8比值上升到正常水平。治疗后患者血清sIL-2R和血清TNF含量较治疗前明显降低,外周血mIL-2R和LFA-1阳性淋巴细胞也有一定增加。结果显示黄芪有显著改善MHD患者细胞免疫功能的作用。
Twenty-one patients with maintenance hemodialysis (MHD) were treated with Huangqi Injection at the same time as dialysis treatment. After 3 months, the immune function of the patients was significantly improved. Compared with normal people, the peripheral blood CD8 T cells, serum sIL-2R levels, serum TNF levels were significantly increased in patients with MHD, while the ratio of CD4/CD8 and lymphocyte mIL-2R positive cells in peripheral blood was significantly decreased, indicating that MHD patients The cellular immune function is reduced. After 3 months of treatment with Huangqi Injection, the ratio of CD4T cells and CD4/CD8 in the peripheral blood of patients was significantly increased, CD8T cells decreased to normal levels, and the ratio of CD4/CD8 increased to normal levels. After treatment, serum sIL-2R and serum TNF levels were significantly lower than before treatment, and peripheral blood mIL-2R and LFA-1 positive lymphocytes also increased. The results showed that Astragalus has a significant effect on improving cellular immune function in patients with MHD.