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AIM: To investigate the hepatic capacity to produceglucose during hypoglycemia induced by insulin (HⅡ).METHODS: Livers from 24-h fasted rats whichreceived ip insulin (HⅡ rats) or saline (control rats)were perfused in situ. The gluconeogenic substratesL-alanine (5 mmol/L), L-glutamine (5 mmol/L),L-lactate (2 mmol/L), and glycerol (2 mmol/L) wereemployed. The gluconeogenic activity was measuredas the difference between rates of glucose released
AIM: To investigate the hepatic capacity to produce glucose during hypoglycemia induced by insulin (HII). METHODS: Livers from 24-h fasted rats whichreceived ip insulin (HII rats) or saline (control rats) were perfused in situ. The gluconeogenic substratesL-alanine L-lactate (2 mmol / L), and glycerol (2 mmol / L) wereemployed. The gluconeogenic activity was measured as the difference between the rates of glucose released