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目的 探讨血清CA12 5水平的测定在妇科肿瘤临床中的应用价值。方法 采用放射免疫分析方法测定 86例妇科肿瘤患者血清CA12 5抗原水平。结果 卵巢上皮癌组CA12 5水平为 2 14 .5 4± 16 8.2 9u/ml,其敏感性为 96 .4% ,特异性为 84.5 % ,该组经手术和化疗后CA12 5水平比治疗前显著降低 (P <0 .0 0 1) ;子宫内膜异位症组CA12 5水平明显高于子宫肌瘤组及卵巢良性肿瘤组。结论 血清CA12 5水平测定对卵巢上皮癌的诊断及预后评估具有重要意义 ,结合临床亦可为子宫内膜异位症的诊断提供有价值的参考。
Objective To investigate the clinical value of serum CA12 5 in gynecologic oncology. Methods Radioimmunoassay was used to determine the level of serum CA12 5 in 86 gynecologic cancer patients. Results The level of CA12 5 in ovarian cancer was 2 14.54 ± 16 8.2 9u / ml, with a sensitivity of 96.4% and a specificity of 84.5%. The level of CA12 5 in patients with epithelial ovarian cancer after operation and chemotherapy was significantly higher than that before treatment (P0.01). The level of CA12 5 in endometriosis group was significantly higher than that in uterine fibroid group and benign ovarian tumor group. Conclusion The determination of serum CA12 5 level is of great significance for the diagnosis and prognosis evaluation of epithelial ovarian cancer. Combining with clinic may provide a valuable reference for the diagnosis of endometriosis.