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探讨微量元素铜和锌在二乙基亚硝胺诱发大鼠实验性肝癌中的变化及意义。用原子吸收光谱法观察血清中微量元素铜和锌的含量 :用分析电镜对实验组与对照组肝组织中微量元素铜和锌进行了原位定性定量分析。结果 :与对照组相比 ,实验组中血清铜水平升高 ,血清锌水平降低及血清铜 /锌比值 ( 1 .53)显著高于对照组 ( 0 .78) ( P<0 .0 5) ,实验组肝癌组织中微量元素铜和锌含量明显低于对照组正常肝组织 ( P<0 .0 5)。结论 :微量元素铜和锌的变化与肝癌的发生发展密切相关 ,血清铜 /锌比值升高可作为肝癌的一个重要标志。
To investigate the changes and significance of trace elements copper and zinc in diethylnitrosamine-induced experimental liver cancer in rats. Atomic Absorption Spectrometry was used to observe the contents of trace elements Cu and Zn in the serum: In situ qualitative and quantitative analysis of trace elements Cu and Zn in the liver tissue of the experimental group and the control group was performed using an SEM. Results: Compared with the control group, serum copper levels in the experimental group increased, serum zinc levels decreased, and serum copper/zinc ratio (1.53) was significantly higher than that in the control group (0.78) (P<0.05). The content of trace elements Cu and Zn in HCC tissue in the experimental group was significantly lower than that in the control group (P<0.05). Conclusion: The changes of trace elements copper and zinc are closely related to the occurrence and development of liver cancer. The increase of serum copper/zinc ratio can be used as an important marker of liver cancer.