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目的探讨降糖药格列苯脲与二甲双胍对2型糖尿病住院患者的有效性和安全性。方法将2型糖尿病患者180例随机分为格列苯脲组和二甲双胍组各90例,观察治疗3月后两组患者空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbAlc)、血压、血脂水平及BMI指数的变化情况。结果治疗后两组患者上述各项指标均一定程度下降,组间差异无统计学意义;格列苯脲组HbA1c下降程度高于二甲双胍组,差异有统计学意义;二甲双胍组低血糖事件发生率低于格列苯脲组,差异有统计学意义。结论格列苯脲与二甲双胍均具有良好的降糖作用,各具优势,可依据不同目的指导患者用药。
Objective To investigate the efficacy and safety of hypoglycemic agents glibenclamide and metformin in inpatients with type 2 diabetes mellitus. Methods 180 patients with type 2 diabetes were randomly divided into two groups: 90 patients in each group were treated with glibenclamide and metformin. FPG, 2hPG, HbAlc, , Blood pressure, blood lipid levels and BMI index changes. Results After treatment, the above indexes in both groups declined to a certain extent, with no significant difference between the two groups. The decrease of HbA1c in glibenclamide group was higher than that in metformin group, the difference was statistically significant. The incidence of hypoglycemia in metformin group was lower In glibenclamide group, the difference was statistically significant. Conclusion Glibenclamide and metformin have a good hypoglycemic effect, each with its own advantages, according to different purposes to guide the patient medication.