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目的:比较盐酸戊乙奎醚与阿托品治疗急性有机磷农药中毒的临床疗效和安全性。方法:急性有机磷农药中毒患者122例,分为盐酸戊乙奎醚组62例,阿托品组60例,分别给予盐酸戊乙奎醚及氯解磷定、阿托品及氯解磷定治疗,比较2组患者症状、体征消失时间、不良反应发生率及治愈率。结果:盐酸戊乙奎醚组治愈率96.8%,阿托品组治愈率91.7%,2组比较差异有统计学意义(P<0.01),且盐酸戊乙奎醚组症状、体征消失时间,治愈时间优于阿托品组,不良反应发生率低于阿托品组,差异有统计学意义(P<0.01)。2组比较盐酸戊乙奎醚作用持续时间长,服药频次少。结论:盐酸戊乙奎醚治疗急性有机磷农药中毒安全、有效,疗效优于阿托品。
Objective: To compare the clinical efficacy and safety of penehyclidine hydrochloride and atropine in the treatment of acute organophosphorus pesticide poisoning. Methods: A total of 122 patients with acute organophosphorus pesticide poisoning were divided into penehyclidine hydrochloride group (n = 62) and atropine group (n = 60). Penehyclidine hydrochloride, chlorpromazine, atropine and chlorpheniramine were given respectively. Group symptoms, signs disappear time, the incidence of adverse reactions and cure rates. Results: The cure rate of penehyclidine hydrochloride group was 96.8%, and the cure rate of atropine group was 91.7%. There was significant difference between the two groups (P <0.01). The symptom, disappearance time and healing time of penehyclidine hydrochloride group were superior In atropine group, the incidence of adverse reactions was lower than atropine group, the difference was statistically significant (P <0.01). Comparison of 2 groups penehyclidine hydrochloride role of long duration, taking less frequently. CONCLUSION: Penehyclidine hydrochloride is safe and effective in the treatment of acute organophosphorus pesticide poisoning. Its curative effect is better than atropine.