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不同浓度的莪液对ＨｅＬａ细胞有不同的毒性。选用合适浓度的莪对呼吸道合胞病毒（ＲＳＶ）有直接灭活作用；对入侵细胞内的ＲＳＶ可能有一定的抑制作用。提示用莪液向呼吸道喷雾治疗呼吸道合胞病毒感染，可能有效。建立了ＲＳＶ感染的Ｂａｌｂ／Ｃ小鼠的动物模型，并用莪静脉注射液进行了实验，治疗感染了ＲＳＶ的Ｂａｌｂ／Ｃ小鼠。在感染ＲＳＶ的第５天和第８天，莪治疗组的鼠肺ＲＳＶ分离率明显低于ＲＳＶ感染组和葡萄糖对照组，Ｐ值分别＜０．００１和＜０．０００１，表明莪对感染ＲＳＶ的动物有体内抑病毒作用。ＲＳＶ感染组和葡萄糖对照组的鼠肺弹性及颜色改变明显不同于莪治疗组，Ｐ值＜０．００１及＜０．００３。对鼠肺组织用光学显微镜和电镜病理检查发现，在第５天，感染ＲＳＶ小鼠的肺血管、毛细支气管区肺泡呈明显水肿和不同程度类症浸润，支气管上皮明显肿胀，可见不同程度的纤毛脱落和局灶性坏死，管腔内的巨噬细胞、多形核白细胞和纤维素形成栓子而致管腔阻塞，管腔内有明显的血小板聚集，肺泡间隔有嗜酸细胞浸润。葡萄糖对照组与ＲＳＶ感染组的病理改变相同。在第５天，莪治疗组小鼠肺的毛细血管内皮细胞大部分正常，仅少数内皮损伤或形成囊泡，管腔内血小板聚集和淋巴细胞数量明显?
Different concentrations of Curcuma liquid HeLa cells have different toxicity. The use of appropriate concentrations of Curcuma on respiratory syncytial virus (RSV) has a direct inactivation; invasion of intracellular RSV may have some inhibitory effect. Prompt use of Curcuma respiratory spray to treat respiratory syncytial virus infection, may be effective. An animal model of Balb / C mice infected with RSV was established and treated with Verapamil for the treatment of Balb / C mice infected with RSV. On the 5th and 8th days of RSV infection, RSV isolation rate of rat lung was significantly lower than that of RSV infection group and glucose control group (P <0.001 and <0.0001, respectively), indicating that RSV The animals have in vivo inhibition of the virus. RSV infection and glucose control group rats lung elasticity and color change was significantly different from the Curcuma treatment group, P values <0.001 and <0.003. The lung tissue of rats was observed by light microscopy and electron microscopy. On the fifth day, pulmonary alveolus and bronchial alveoli in RSV-infected mice showed obvious edema and infiltration of different degrees, and the bronchial epithelium was obviously swollen with varying degrees of cilia Shedding and focal necrosis, intraluminal macrophages, polymorphonuclear leucocytes and cellulose emboli caused by obstruction of the lumen, the lumen has significant platelet aggregation, alveolar septa with eosinophilic infiltration. The glucose control group had the same pathological changes as the RSV infection group. On the fifth day, most of the capillary endothelial cells in the lungs of the mice in normal control group were normal, only a few endothelial injuries or vesicles were formed, and the platelet aggregation and the number of lymphocytes in the lumen were obvious.