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目的 :探讨支气管哮喘患者的个性、生活事件及心理健康状况与相关细胞因子白介素 (IL) :IL -2、IL -4、IL -8、IL -10、γ -干扰素 (IFN -γ)和内皮素 (ET -1)在发病过程中变化的相关性。方法 :对 60例支气管哮喘患者和 3 0例对照者 ,进行了艾森克人格 (EPQ)、生活事件 (LES)和心理健康状况 (SCL-90 )评定及IL -2、IL -4、IL -8、IL -10、IFN -γ与ET -1检测。结果 :病人组EPQ测试 :E得分明显低于对照组 (P <0 0 5 ) ,N得分高于对照组 (P <0 0 5 ) ;P、L得分虽有差异但无统计学意义 ;生活事件总分 ,病人组明显高于对照组 (P <0 0 1) ;SCL -90测评 :病人组除偏执、精神病因子分与对照组差异无统计学意义外 (P >0 0 5 ) ,其余因子分和总分研究组高于对照组 ,差异有显著性 (P <0 0 5、 0 0 1)。血清IL -2、IL-10和IFN -γ研究组低于对照组 (P <0 0 1) ,IL -4、IL -8和ET -1研究组高于对照组 (P <0 0 5、 0 0 1)。相关性分析显示 ,在支气管哮喘发病过程中IL -2、IL -10和IFN -γ的变化与性格E呈正相关 (r =0 2 4、0 3 6、 0 40 ,P <0 0 5、 0 0 1) ,与性格N呈负相关 (r =-0 3 3、 -0 3 5、 -0 3 0 ,P <0 0 5、 0 0 1) ;而IL -4、IL -8和ET -1与性格E呈负相关 (r =-0 3 3、 -0 42、 -0
Objective: To investigate the relationship between personality, life events and mental health of patients with bronchial asthma and related cytokines interleukin (IL): IL -2, IL -4, IL -8, IL -10, IFN - γ and Endothelin (ET-1) changes in the pathogenesis of the correlation. Methods: The 60 patients with bronchial asthma and 30 controls were evaluated for EPQ, LES and SCL-90, and the levels of IL-2, IL-4, IL -8, IL-10, IFN-γ and ET-1. Results: In EPQ test, the score of E was significantly lower than that of control group (P <0.05), N score was higher than that of control group (P <0 05); P and L scores were not statistically significant The total scores of patients and patients were significantly higher than that of the control group (P <0.01). SCL-90 was not significantly different between the paranoid and psychiatric patients and the control group (P> 0.05) Factor scores and total score of the study group than the control group, the difference was significant (P <0 0 5, 0 0 1). Serum levels of IL-2, IL-10 and IFN-γ in the study group were lower than those in the control group (P <0.01), IL-4, IL-8 and ET-1 in the study group were higher than those in the control group 0 0 1). Correlation analysis showed that there was a positive correlation between the changes of IL-2, IL-10 and IFN-γ and character E in the pathogenesis of bronchial asthma (r = 0 2 4, 0 3 6, 0 40, P 0 05, 0 0 1), but negatively correlated with personality N (r = -0.33, -0.35, -0.30, P <0.05, 0.01) 1 was negatively correlated with personality E (r = -0 3 3, -0 42, -0