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动物的血脑屏障对异物侵入有排斥作用,但也排斥药物对脑疾病的治疗。日本名古屋大学医学部八木国夫教授,发明用糖脂类作脑的人工膜,用人工膜(微脂粒)包着酶注入大白鼠脑内,破坏血脑屏障,获得成功。用这种方法,对酶缺陷引起的先天性代谢疾病、脑肿瘤、脑转移癌等,开辟了新的药物治疗途径。先天性脑的各种酶缺陷的遗传病,到目前已确认有8种。GN_1—神经节苷脂酶缺陷是其中之一,这种病是因能分解神经节苷脂的糖脂质的酶,β—半乳糖甙酶(β-galactosidase)缺少,这种脂质在脑中逐渐沉
The animal’s blood-brain barrier rejects invasion of foreign bodies, but it also excludes the treatment of brain diseases by drugs. Japan Nagoya University Medical Professor Yagi Kunimi, the invention of glycolipids brain artificial film, with artificial membrane (liposomes) wrapped enzyme injected into the brain of rats, damaging the blood-brain barrier, to be successful. In this way, the enzyme deficiency caused by congenital metabolic diseases, brain tumors, brain metastases, etc., opened up a new drug treatment. Congenital brain enzymes of various genetic defects, so far has confirmed that there are eight. GN 1 1-gangliosidase deficiency is one of these diseases is due to the decomposition of gangliosides glycolipid enzymes, β-galactosidase deficiency (β-galactosidase), this lipid in the brain Shen gradually