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目的观察益气温阳活血法联用西医常规治疗对慢性充血性心力衰竭患者神经内分泌的影响。方法将63例住院患者随机分为两组,对照组31例采用西医常规治疗(洋地黄、利尿剂、血管扩张药、血管紧张素转换酶抑制剂等),治疗组32例在此基础上加用益气温阳活血中药,2周为1个疗程。用放射免疫法测定治疗前后血浆血管紧张素Ⅱ(AngⅡ)、内皮素(ET)及醛固酮(ALD)值的变化,并与健康人22例对比;同时治疗前后观察左室射血分数(EF)及血液流变学指标。结果充血性心力衰竭患者血浆AngⅡ、ET和ALD水平明显高于健康人,治疗组治疗后上述三项指标均显著降低;同时治疗组治疗后EF值和血液流变学指标有明显改善,与治疗前比较差异显著;治疗组心功能改善总有效率(93.75%)明显高于对照组(77.42%),其差异有显著性。结论益气温阳活血法可抑制神经内分泌系统过度激活,改善充血性心力衰竭患者心功能及血液流变学指标。
Objective To observe the effect of Yiqi Wenyanghuoxue method combined with routine western medicine on neuroendocrine in patients with chronic congestive heart failure. Methods Sixty-three inpatients were randomly divided into two groups. The control group received conventional western medicine (digitalis, diuretic, vasodilator, angiotensin converting enzyme inhibitor, etc.) in 31 patients in the control group. On the basis of the above, Use Qi Yang Yang Huoxue medicine, 2 weeks for a course of treatment. The levels of plasma angiotensin Ⅱ (AngⅡ), endothelin (ET) and aldosterone (ALD) were measured by radioimmunoassay before and after treatment. The changes of plasma endothelin (ET) and aldosterone (ALD) And blood rheology indicators. Results The levels of plasma AngⅡ, ET and ALD in patients with congestive heart failure were significantly higher than those in healthy people. The three indexes in the treatment group were significantly lower after treatment. The EF and hemorheology indexes in the treatment group were significantly improved after treatment, Before treatment, the total effective rate of improvement of cardiac function (93.75%) was significantly higher than that of the control group (77.42%), the difference was significant. Conclusion Yiqi Yangyanghuoxue Decoction can inhibit neuroendocrine system over-activation and improve cardiac function and hemorheology in patients with congestive heart failure.