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梗阻性黄疸(简称阻黄)术后发生肾衰的危险性很大,死亡率高达25～80%。这与内毒素血症有关。内毒素(即革兰氏阴性菌细胞壁内的脂多糖)可引起肾血管收缩,肾皮质血流减少,使肾小管甚至肾皮质发生坏死。大多数阻黄患者并不存在感染灶,其内毒素系由肠道吸收。本文观察黄疸和无黄疸患者的肠道菌群与内毒素血症的关系及胆盐的预防作用。阻黄和无黄疸患者各25例,年龄、性别及上腹部手术范围均相仿。另外8例阻黄患者术前口服脱氧胆酸
Obstructive jaundice (referred to as yellow) after the risk of renal failure is very high, the mortality rate as high as 25 to 80%. This is related to endotoxemia. Endotoxin (ie, lipopolysaccharide in Gram-negative bacteria cell wall) can cause renal vasoconstriction, reduced renal cortical blood flow, necrosis of renal tubules and even renal cortex. Most patients with yellow blocking infection does not exist, the endotoxin by the intestinal absorption. This article observed jaundice and jaundice in patients with intestinal flora and the relationship between endotoxemia and bile salt prevention. Anti-yellow and jaundice in patients with 25 cases of each age, gender and upper abdominal surgery are similar. Another 8 patients with yellow blocking oral deoxycholic acid