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目的 观察不同三联方案“丽珠胃三联”药物搭配、疗程和剂量的效果来探索较理想的治疗幽门螺杆菌 (Hp)的方案。 方法 Hp阳性的十二指肠溃疡 12 6例、胃溃疡 40例。随机分成三组 :A组 :枸橼酸铋钾 0 .2 2 g/次 +克拉霉素 0 .2 5g/次 +替硝唑 0 .5 g/次 ,称“丽珠胃三联” ,均为 2次 /d ,疗程7d ;B组 :药物组成、用法同A组 ,但疗程为 14d ;C组 :奥美拉唑 2 0mg ,甲硝唑 40 0mg ,阿莫西林 1g ,均为 2次 /d ,疗程 7d。观察记录Hp根除情况、溃疡愈合情况、临床症状改善情况及不良反应。结果 16 0例完成治疗及复查 ,失访 6例。Hp根除率A、B、C三组分别为 87.9% ,87.0 % ,86 .8% ,差异无显著性 (P>0 .0 5 ) ;胃溃疡治疗后的总有效率分别为 92 .3% ,90 .9%及 92 .9% ;十二指肠溃疡治疗后的总有效率分别为 97.8% ,10 0 %及 92 .1% ,二项三组差异均无显著性 (P >0 .0 5 ) ;三组均有轻微不良反应 ,但不影响治疗。结论 “丽珠胃三联”7d治疗方案具有药物剂量小、疗程短、疗效高、价格低等特点 ,是较为理想的根除Hp、治愈溃疡、降低溃疡复发率的方案
Objective To observe the effects of different combinations of “Livzon stomach triple therapy” with medication, course of treatment and dose to explore a more ideal plan for the treatment of Helicobacter pylori (Hp). Methods Hp-positive duodenal ulcer 12 6 cases, 40 cases of gastric ulcer. Randomly divided into three groups: A group: bismuth potassium citrate 0 .2 2 g / times + clarithromycin 0.52g / times + tinidazole 0.5g / times, called “Livat stomach triple”, both For 2 times / d, treatment for 7d; group B: drug composition, usage with group A, but the treatment for 14d; group C: omeprazole 20mg, metronidazole 40mg, amoxicillin 1g, / d, treatment 7d. Observe Hp eradication, ulcer healing, clinical symptoms and adverse reactions. Results 16 0 cases completed treatment and review, lost in 6 cases. The eradication rate of Hp in group A, B and C were 87.9%, 87.0% and 86.8% respectively, with no significant difference (P> 0.05). The total effective rates of gastric ulcer after treatment were 92.3% , 90.9% and 92.9% respectively. The total effective rates of duodenal ulcer after treatment were 97.8%, 100% and 92.1% respectively. There was no significant difference between the three groups (P> 0.05). 0 5). All three groups had mild adverse reactions, but did not affect the treatment. Conclusion The “Livzon triple therapy” treatment program has the characteristics of small dosage, short course of treatment, high curative effect and low price, which is an ideal solution to eradicate Hp, cure ulcer and reduce ulcer recurrence rate