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目的探讨纳洛酮联合氨茶碱治疗早产儿原发性呼吸暂停的疗效。方法选择2008-11-2010-11收治的早产儿原发性呼吸暂停62例患儿。入院后均给予暖箱保暖,维持血糖、血压、酸碱平衡稳定,保证气道通畅,生命体征监测,静脉营养,维生素C,ATP等支持对症基本治疗。对照组使用氨茶碱,首剂5mg/kg,0.5h内静脉滴入,12h后予维持量2mg/kg,每12h一次;治疗组在上述基础上加用纳洛酮0.1mg/(kg.次),每8h一次静脉泵入,与氨茶碱交替使用,两组治疗至呼吸暂停消失后减停。结果治疗组显效20例(62.5%),有效9例(28.1%),无效3例(9.4%),总有效率90.6%;对照组显效13例(43.3%),有效7例(23.3%),无效10例(33.3%),总有效率66.6%。治疗组和对照组总有效率比较,差异有统计学意义(χ2=5.36,P<0.05)。结论纳洛酮与氨茶碱联合应用优于氨茶碱单独应用治疗早产儿原发性呼吸暂停,且用药安全性高,加上纳洛酮价格低廉,配制简便,故值得基层医院推广应用。
Objective To investigate the efficacy of naloxone combined with aminophylline in the treatment of premature infants with primary apnea. Methods Sixty-two children with primary apnea of premature infants admitted to our hospital from 2008-11-2010-11 were enrolled. After admission are warm incubator to maintain blood sugar, blood pressure, acid-base balance and stability, to ensure airway patency, vital signs monitoring, intravenous nutrition, vitamin C, ATP and other symptomatic treatment support basic treatment. The control group used aminophylline, the first dose of 5mg / kg, 0.5h intravenous infusion, 12h after the maintenance dose of 2mg / kg, once every 12h; the treatment group based on the above plus naloxone 0.1mg / (kg. Times), once every 8h intravenous infusion, and aminophylline used interchangeably, the two groups until the treatment of apnea stopped. Results The effective rate of the treatment group was 20 (62.5%), 9 (28.1%) were effective, 3 (9.4%) were ineffective, and the total effective rate was 90.6% , Ineffective in 10 cases (33.3%), the total effective rate 66.6%. The total effective rate of treatment group and control group, the difference was statistically significant (χ2 = 5.36, P <0.05). Conclusion The combination of naloxone and aminophylline is superior to aminophylline alone in the treatment of primary apnea in preterm infants, and the drug is safe, with low price of naloxone and easy preparation. Therefore, it is worth popularizing and applying in primary hospitals.