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目的探讨HELLP综合征时血小板参数及直方图变化规律。方法用血细胞分析仪对17例HELLP综合征患者血小板相关参数进行检测。结果HELLP综合征患者组与重度子痫前期组相比较,血小板PLT明显降低,血小板体积分布宽度PDW和MPV血小板平均容积明显增大,差异有统计学意义(P<0.001),HELLP综合征组与重度子痫前期组PLT数值均明显低于正常孕妇组,PDW和MPV也明显大于正常孕妇组(P<0.001)。结论血小板计数和血小板相关参数及血小板图形,不失为HELLP综合征早发现的指标,妊高征患者动态监测血小板相关参数及图形变化规律,早期发现HELLP综合征,可大大降低母儿死亡率。
Objective To investigate the changes of platelet parameters and histogram in HELLP syndrome. Methods The hematology analyzer was used to detect platelet-related parameters in 17 patients with HELLP syndrome. Results Compared with the severe preeclampsia group, the PLT of platelet in HELLP syndrome group was significantly decreased, the platelet volume distribution width PDW and MPV platelet volume were significantly increased, the difference was statistically significant (P <0.001), HELLP syndrome group PLT values in severe preeclampsia group were significantly lower than those in normal pregnant women, and PDW and MPV were also significantly higher than those in normal pregnant women (P <0.001). Conclusions Platelet count, platelet related parameters and platelet pattern are indicators of early detection of HELLP syndrome. In the patients with PIH, the platelet parameters and pattern changes were dynamically monitored. Early detection of HELLP syndrome could greatly reduce maternal mortality.