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蒿甲醚混悬液总量120～800 mg/kg,分1～4天给,灌胃治疗病鼠和病免,减虫率为55.3％～88.5％;总量25～35 mg/kg,分3天给治疗病犬,减虫率为52.6％～59.1％。蒿甲醚油剂以225～435 mg/kg,分3天给,皮下注射治疗病鼠,减虫率为70.5％～81.2％;总量200～400mg/kg和150～250 mg/kg,分4～5天给分别肌注治疗病兔和病犬,减虫率分别为85.9％～90.7％和91.3％～99.3％。犬每天肌注油剂30～90 mg/kg,连注5天,出现较明显的胃肠道刺激症壮,组织学检查出现胃肠道、肝、肾等组织的可逆性病理损害。
Artemether suspension total 120 ~ 800 mg / kg, 1 to 4 days to give gavage treatment of disease and disease-free mice, worm reduction rate was 55.3% ~ 88.5%; total 25 ~ 35 mg / kg, Divided three days to treat sick dogs, worm reduction rate was 52.6% ~ 59.1%. Artemether oil at 225 ~ 435 mg / kg in 3 days, subcutaneously treated rats, the worm reduction rate was 70.5% ~ 81.2%; total 200 ~ 400mg / kg and 150 ~ 250 mg / kg, Four to five days for the treatment of rabbits and dogs were intramuscular injection respectively, the worm reduction rates were 85.9% ~ 90.7% and 91.3% ~ 99.3%. Dog oil daily 30 ~ 90 mg / kg, with a continuous injection of 5 days, there was more obvious gastrointestinal irritation, histological examination showed gastrointestinal tract, liver, kidney and other reversible pathological tissue damage.