心血管疾病是引起终末期肾病患者死亡的主要因素,导致心血管疾病的关键因素则为动脉粥样硬化。慢性肾脏病患者动脉粥样硬化的发生率较同一年龄人群高5~10倍,发病年龄提前至30~40岁,被称为加速型动脉粥样硬化。该文主要从微炎症状态、高同型半胱氨酸血症、不同血液净化方式、营养不良、基因多态性与动脉粥样硬化关系等方面,介绍终末期肾病患者加速型动脉粥样硬化相关机制的研究进展,并简要介绍相关的干预措施。 Cardiovascular disease is a major cause of death in patients with end-stage renal disease, leading to atherosclerosis as a key contributor to cardiovascular disease. The incidence of atherosclerosis in patients with chronic kidney disease is 5 to 10 times higher than in the same age population and the age at onset is 30 to 40 years old, which is called accelerated atherosclerosis. This article mainly introduces the accelerated atherosclerosis related to end-stage renal disease from the aspects of micro-inflammation, hyperhomocysteinemia, different blood purification methods, malnutrition, genetic polymorphism and atherosclerosis Mechanism of research progress, and a brief introduction of the relevant interventions.