与鼠单克隆抗体(以下简称单抗)相比,人单抗具有许多优越性。然而人单抗制备比鼠单抗困难得多,主要原因之一是缺乏理想的亲本细胞株。人们先后利用鼠骨髓瘤,人浆细胞瘤和人淋巴母细胞瘤制备人单抗,均不尽人意。后来,人们利用人一鼠种间骨髓瘤制备人单抗,发现其融合率高,抗 Compared with the mouse monoclonal antibody (hereinafter referred to as monoclonal antibody), human monoclonal antibody has many advantages. However, one of the main reasons why human Mab was more difficult to prepare than Mab was the lack of ideal parental cell lines. People have using murine myeloma, human plasmacytoma and human lymphoblastoma preparation of human monoclonal antibody, are less than satisfactory. Later, people using human and mouse interstitial myeloma human monoclonal antibody was found, the fusion rate was high, anti