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乙型肝炎e抗原(HBeAg)是乙型肝炎病毒(HBV)感染的血清学标志之一,同时又是乙型肝炎诊断上的一种重要的生物制剂。HBV感染之后,血清中最早出现的是乙型肝炎表面抗原(HBsAg)和HBeAg。后者的出现表明HBV仍在活跃地复制,此时传染性最强。HBeAg一般在HBsAg消失之前消失,如果持续阳性达8到10周以上,说明已转变成慢性肝病。HBeAg相应抗体抗-HBe的出现表明病毒复制已停止,传染力低,也是HBV感染将过的征兆。因此对于HBsAg阳性患者,为了了解HBV感染的状况及将来可能的发展,同时检查HBeAg和抗-HBe具有重要的意义。日前用于临床诊断的HBeAg主要是从病人血浆中提取的,由于材料缺乏,远远不能满足实际需要。
Hepatitis B e antigen (HBeAg) is one of the serological markers of hepatitis B virus (HBV) infection and is an important biological agent in the diagnosis of Hepatitis B. After HBV infection, the first occurrence of serum hepatitis B surface antigen (HBsAg) and HBeAg. The latter appears to indicate that HBV is still actively replicating and is most contagious at this time. HBeAg generally disappeared before the disappearance of HBsAg, if the persistent positive for 8 to 10 weeks or more, indicating that has been converted to chronic liver disease. The appearance of anti-HBe, the corresponding antibody to HBeAg, indicates that viral replication has stopped and the infectivity is low, which is also an indication of HBV infection. Therefore, HBsAg-positive patients, in order to understand the status of HBV infection and possible future development, simultaneous examination of HBeAg and anti-HBe is of great significance. Recently, HBeAg used for clinical diagnosis is mainly extracted from the patient’s plasma, due to lack of material, far from meeting the actual needs.