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目的 :探讨转化生长因子 β1(TGF β1)在多发性硬化 (MS)发生、发展中的作用。方法 :采用酶联免疫吸附ELISA方法 ,对 45例MS患者血清TGF β1的含量进行了测定。结果 :与对照组和NIND组相比 ,MS患者血清TGF β1含量明显下降 (P <0 0 1) ;与StableMS组相比 ,RRMS组和CPMS组TGF β1含量亦明显下降 (P <0 0 5 ) ;动态观察显示 ,随着病情的好转 ,TGF β1含量亦逐渐升高。结论 :血清中TGF β1的检测对判断MS患者的病情变化具有重要的临床实用价值。
Objective: To investigate the role of transforming growth factor β1 (TGF β1) in the occurrence and development of multiple sclerosis (MS). Methods: Serum TGFβ1 levels in 45 MS patients were determined by enzyme-linked immunosorbent assay (ELISA). Results: Compared with control group and NIND group, serum TGF-β1 level in MS patients decreased significantly (P <0.01). Compared with StableMS group, TGFβ1 levels in RRMS group and CPMS group also decreased significantly (P <0.05 ); Dynamic observation showed that with the improvement of the disease, TGFβ1 content also gradually increased. Conclusion: The detection of TGFβ1 in serum has important clinical practical value in judging the change of MS patients.