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目的探讨CRP在Graves病发展中的影响及临床意义。方法研究对象分Graves病初发组、缓解组、完全缓解组、复发组及正常对照组,检测CRP含量及TSH。结果 CRP正常对照组结果为(0.21±0.14)mg/dl,初发组结果为(0.41±0.52)mg/dl,缓解组结果为(0.18±0.08)mg/dl,完全缓解组结果为(0.31±0.26)mg/dl,复发组结果为(0.19±0.13)mg/dl;初发组结果明显高于正常对照组、缓解组,差异有统计学意义(P分别为0.005、0.011),其余各组别比较虽有差异,但没有统计学意义;CRP与TSH低相关,无统计学意义。结论 CRP在GD中参与免疫反应,对治疗有临床意义,可能为GD病理机制的探讨提供新的线索。
Objective To investigate the impact of CRP on the development of Graves disease and its clinical significance. Methods The subjects were divided into primary disease group, remission group, complete remission group, relapse group and normal control group, and the levels of CRP and TSH were detected. Results The CRP in the control group was (0.21 ± 0.14) mg / dl, in the initial treatment group was (0.41 ± 0.52) mg / dl, in the remission group was (0.18 ± 0.08) mg / dl and in the complete remission group was ± 0.26) mg / dl, and the recurrence group was (0.19 ± 0.13) mg / dl. The outcome in the primary group was significantly higher than that in the normal control group and remission group (P = 0.005 and 0.011, respectively) Although there are differences between groups, but no statistical significance; CRP and TSH low correlation, no statistical significance. Conclusion CRP is involved in immune response in GD, which has clinical significance for treatment and may provide new clues for the study of pathological mechanism of GD.