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氨茶碱是一种有效的支气管扩张药,但它的治疗指数比较狭窄。当茶碱的血清浓度超过一定的治疗范围(一般认为10～20μg/ml)时出现恶心、呕吐、心律不齐、惊厥、甚至死亡。因此,根据临床诊断和治疗的情况,应用药物动力学原理,监护氨茶碱的临床应用是很重要的。本文介绍了我院对10例哮喘患者进行血药浓度测定和个体化给药方案设计,同时进行临床观察的情况。
Aminophylline is a potent bronchodilator, but its therapeutic index is relatively narrow. When the theophylline serum concentration exceeds a certain range of treatment (generally considered 10 ~ 20μg / ml) nausea, vomiting, arrhythmia, convulsions and even death. Therefore, based on the clinical diagnosis and treatment of the situation, the application of pharmacokinetic principles, monitoring the clinical application of aminophylline is very important. This article describes our hospital on the 10 cases of asthma patients blood concentration determination and individualized drug delivery program design, clinical observation at the same time.