多种抗癌剂具有变异原性、致癌性和致畸性,对男性患者也影响到生育能力和后代,这对青壮年恶性肿瘤患者,是一个不容忽视的问题。关于抗癌剂的细胞毒性影响到精子形成和成熟过程中的哪个阶段和带来什么样的变化,不得不依赖于动物实验。据报道,大量投予环磷酰胺(CPX,50～100mg/kg)可引起睾丸重量减轻,一过性精子缺乏症,精原细胞DNA合成低下,精子细胞蛋白合成减少,发生致死性突变和遗传给后代的染色体异常等。目前尚无关于化疗维持量,或用作免疫抑制疗法的少量连日投药造成影响的报道。Trasler等给雄性鼠投予CPX1.4、3.4和5.1mg/kg.d,1～11周,使之在发情期与雌性鼠交配,在妊娠第22日宰杀,探讨受孕前的精子丧失量(黄体数与受孕数之差)和受孕后的丧失量(受孕数与生育胎数之差),进而研究下丘脑、垂体和睾丸系统的内分泌学变化。结果表明,少量连日投予,雄性生殖系器官的重量,副睾的精子数量等未见改变。最 A variety of anti-cancer agents with variability, carcinogenicity and teratogenicity, male patients also affect fertility and offspring, which for young patients with malignant tumors is a problem that can not be ignored. Cytotoxicity of anticancer agents affects which stage in the process of spermatogenesis and maturation and what changes have to be made that have to rely on animal experiments. It has been reported that large doses of cyclophosphamide (CPX, 50-100 mg / kg) can cause testicular weight loss, transient sperm deficiency, low DNA synthesis in spermatogonia, reduced sperm cell protein synthesis, fatal mutations and inheritance Chromosome abnormalities to future generations. There are no reports of the impact of chemotherapy maintenance or small daily doses of immunosuppressive therapy. Trasler et al. Administered male CPX 1.4, 3.4 and 5.1 mg / kg.d for 1 to 11 weeks to mate females during estrus and slaughtered on day 22 of gestation to investigate sperm loss before conception ( Luteal number and the difference between the number of conception) and loss after conception (the difference between the number of conception and the number of births), and then study the endocrine changes of the hypothalamus, pituitary and testicular system. The results showed that a small amount of continuous administration, the weight of male reproductive organs, sperm number of epididymis unchanged. most