论文部分内容阅读
上皮-间质转化(epithelial-to-mesenchymal transition,EMT)是肿瘤侵袭和转移的首要步骤。ZEB1是EMT的关键转录因子之一,在肺癌EMT发生中起重要作用。ZEB1受LKB1等抑癌基因突变、miRNAs(如miR-200、miR-34a)水平、炎症或低氧肿瘤微环境等肺癌细胞内外因素的影响,主要通过抑制E-cadherin表达,引起肺癌细胞表型间质化。此外,ZEB1诱导肺癌EMT可能与TGF-β、COX-2等信号转导途径有关。
Epithelial-to-mesenchymal transition (EMT) is the first step in tumor invasion and metastasis. ZEB1 is one of the key transcription factors of EMT and plays an important role in the development of EMT in lung cancer. ZEB1 is affected by mutations in LKB1 and other cancer cells, miRNAs (such as miR-200, miR-34a), inflammatory or hypoxic tumor microenvironment and other factors, mainly through the inhibition of E-cadherin expression, causing lung cancer cell phenotype Interstitial. In addition, ZEB1 induced EMT in lung cancer may be related to TGF-β, COX-2 and other signal transduction pathways.