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目的观察新辅助化疗联合腹腔镜手术治疗低位直肠癌对血清癌胚抗原(CEA)、肿瘤标记物CA242、CA724水平的影响。方法将240例低位直肠癌患者随机分为试验组和对照组各120例。对照组采用腹腔镜手术治疗,试验组采用新辅助化疗联合腹腔镜手术治疗。比较2组患者治疗前后血清CEA、CA242、CA724的水平。结果 2组患者治疗后CEA、CA242、CA724水平均低于治疗前,且试验组均低于对照组,差异均有统计学意义(P<0.05)。结论新辅助化疗联合腹腔镜手术治疗低位直肠癌能有效改善患者血清CEA、CA242、CA724水平,能有效缓解患者的病情,临床疗效优于单纯使用腹腔镜手术治疗,值得推广应用。
Objective To observe the effect of neoadjuvant chemotherapy combined with laparoscopic surgery on the level of serum carcinoembryonic antigen (CEA) and tumor markers CA242 and CA724 in patients with low rectal cancer. Methods 240 patients with low rectal cancer were randomly divided into experimental group and control group of 120 cases. The control group was treated with laparoscopic surgery, the experimental group with neoadjuvant chemotherapy combined with laparoscopic surgery. The levels of serum CEA, CA242 and CA724 in two groups before and after treatment were compared. Results After treatment, the levels of CEA, CA242 and CA724 in both groups were lower than those before treatment, and the levels of CEA, CA242 and CA724 in the two groups were lower than those in the control group (P <0.05). Conclusion Neoadjuvant chemotherapy combined with laparoscopic surgery for low rectal cancer can effectively improve the serum CEA, CA242, CA724 levels, which can effectively relieve the patient’s condition. The clinical effect is better than the simple use of laparoscopic surgery, which is worth popularizing and applying.