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通过聚乳酸二元醇和聚乳酸-聚己内酯共聚物二元醇与六亚甲基二异氰酸酯(HDI)三聚体交联反应合成了一系列生物基热固性聚氨酯(Bio-PUs)。利用傅里叶红外(FTIR)、差示扫描量热分析(DSC)、热失重分析(TGA)、万能拉伸机和细胞毒性等测试方法对获得的聚乳酸基聚氨酯进行了表征。结果表明,与聚乳酸二元醇相比,聚乳酸-聚己内酯共聚物二元醇降低了生物基热固性聚氨酯的玻璃化温度(Tg),提高了热固性聚氨酯的热稳定性;且聚乳酸-聚己内酯型聚氨酯的力学性能和形状记忆性能更为优异。其中,聚乳酸-聚己内酯共聚物二元醇分子量为3 000时得到的热固性聚氨酯(Bio-PU2-3000)的杨氏模量为277.7 MPa,伸长率为230%;聚乳酸-聚己内酯共聚物二元醇分子量为1 000得到的热固性聚氨酯(Bio-PU2-1000)在人体体温下的形变回复时间仅为93 s。另外,通过显微镜观察到细胞在含聚乳酸基热固性聚氨酯的培养液中生长状态良好,表明制备得到的生物基聚氨酯无细胞毒性。
A series of bio-based thermosetting polyurethanes (Bio-PUs) were synthesized by the cross-linking of polylactic acid diols and polylactic acid-polycaprolactone copolymer diols with hexamethylene diisocyanate (HDI) trimer. The polylactic acid-based polyurethane was characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), universal tensile tester and cytotoxicity test. The results showed that polylactic acid-polycaprolactone copolymer glycol reduced the glass transition temperature (Tg) of bio-based thermosetting polyurethane and increased the thermal stability of thermosetting polyurethane compared with polylactic acid glycol. Polylactic acid - Polycaprolactone polyurethane has superior mechanical properties and shape memory properties. Among them, the thermosetting polyurethane (Bio-PU2-3000) obtained when the polylactic acid-polycaprolactone copolymer diol has a molecular weight of 3000 has a Young’s modulus of 277.7 MPa and an elongation of 230%; and polylactic acid-poly Caprolactone copolymer diol molecular weight of 1,000 obtained thermosetting polyurethane (Bio-PU2-1000) in the human body temperature deformation response time is only 93s. In addition, the cells were observed under a microscope to grow well in the culture solution containing the polylactic acid-based thermosetting polyurethane, indicating that the prepared bio-based polyurethane has no cytotoxicity.