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在医学实验研究中,大鼠常被选为实验对象。有些实验需要麻醉,以往一直沿用乙醚、乌拉坦和戊巴比妥类药物,前者麻醉时操作程序多且麻醉后需人护理,后两药近年来药品来源困难,且易过量抑制呼吸中枢死亡。我们探索用不同剂量氯胺酮行实验大鼠麻醉,报告如下: 材料与方法一、第一批:随机取本院动物室繁养的一级远交系SD大鼠37只,Wistar大鼠10只,共47只,体重200—350g,用国产氯胺酮加注射用水配成1％浓度行大鼠腹腔注射,分为每100g体重注射<8mg、10—15mg、16—26mg和≥30mg四组剂量,观察注药后出现麻醉时间(以大鼠自然倒下,头、肢体不动,捏尾或针刺皮肤无反应为指标)及麻
In medical experiments, rats were often chosen as subjects. Some experiments require anesthesia, ether, urethane and pentobarbital drugs have been used in the past, the former operating procedures when anesthesia and anesthesia after taking care of people, the latter two drugs in recent years, the source of the drug is difficult, and easy to suppress excessive respiratory death. We explored different doses of ketamine experimental rat anesthesia, the report is as follows: Materials and methods First, the first batch: Randomly taken our hospital animal room first-level outbred SD rats 37, Wistar rats 10, A total of 47, weight 200-350g, with ketamine plus water injection made 1% concentration in rats intraperitoneal injection, divided into 100g body weight injection <8mg, 10-15mg, 16-26mg and ≥ 30mg four doses observed After the injection of anesthesia time (to fall naturally in rats, head, limb immobility, pinch tail or acupuncture skin no reaction as an indicator) and hemp