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目的:探讨糖尿病肾病早期实验室监测指标及其与糖尿病病程的关系。方法对306例糖尿病不同病程患者及100例健康对照者尿蛋白定性和尿微量白蛋白(mAlb)、-微球蛋白(-m)和免疫球蛋白G(IgG)定量检测结果进行统计分析。方法:对306例糖尿病不同病程患者及100例健康对照者尿蛋白定性和尿微量白蛋白(mAlb)、-微球蛋白(-m)和免疫球蛋白G(IgG)定量检测结果进行统计分析。结果:糖尿病(DM)组尿蛋白定性及尿微量白蛋白(mAlb)、-微球蛋白(-m)、和免疫球蛋白G(IgG)定量检测异常结果均明显高于健康对照组,其差异有统计学意义;糖尿病组中,尿蛋白定性阳性率22.5%;尿mAlb、-m、IgG阳性率分别为54.9%、63.7%、和22.7%;尿mAlb和尿-m联合检测总阳性率为75.5%,且糖尿病患者随病程进展尿mAlb和尿-m水平不断升高,尿蛋白定性、尿mAlb和尿-m阳性检出率不断增高。结论:糖尿病患者尿蛋白定性阴性不能排除早期肾损伤,尿mAlb和尿-m检测是糖尿病肾病早期诊断和病程监测的灵敏指标。对于糖尿病患者,定期进行尿mALB和尿-m指标的单项或联合检测,可以早期发现患者肾功能改变,有利于防止和延缓的糖尿病肾病(DN)发生。
Objective: To investigate the early laboratory monitoring of diabetic nephropathy and its relationship with the course of diabetes. Methods The urine samples were collected from 306 patients with different stages of diabetes mellitus and 100 healthy controls, and the urine samples were collected for quantitative analysis of the quantitative results of urinary albumin (mAb), microglobulin (-m) and immunoglobulin G (IgG). Methods: The urine protein qualitative and urinary microalbumin (mAlb), microglobulin (-m) and immunoglobulin G (IgG) were quantitatively analyzed in 306 diabetic patients with different course of disease and 100 healthy controls. Results: The urine protein in DM group and the quantitative detection of urinary microalbumin (mAlb), microglobulin (-m), and immunoglobulin G (IgG) in DM group were significantly higher than those in healthy control group The positive rate of urine mAlb, -m, IgG were 54.9%, 63.7%, and 22.7%, respectively; the positive rate of urine mAlb and urine-m was 75.5%. And the level of urinary mAlb and urinary-m in patients with diabetes mellitus continuously increased, the proteinuria of urine, the positive rate of urine mAlb and urine-m increased continuously. Conclusion: The negative urine protein of diabetic patients can not rule out the early renal injury, urine mAlb and urine-m detection of diabetic nephropathy early diagnosis and monitoring of disease sensitivity indicators. For patients with diabetes, regular urine mALB and urine-m indicators of single or combined detection of early changes in patients with renal function can be conducive to prevent and delay the occurrence of diabetic nephropathy (DN).