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本文研究了西洋人参皂甙(GQS)的抗心律失常作用。GQS 60mg/kg i.v.对氯仿诱发小鼠室颤具有保护作用,与对照组相比可使室颤发生率降低73.4%。GQS 80mg/kg i.v,对氯化钡诱发大鼠心律失常具有明显的预防和治疗作用。GQS 80mg/kg i.v,能明显提高哇巴因诱发豚鼠室早、室速、室扑颤以及停搏的阈剂量。GQS 60mg/kg、80mg/kg i.v,对垂体后叶制剂所致大鼠心肌缺血和心律失常均有明显拮抗作用。GQS 对乌头碱诱发大鼠心律失常则无效。
This study investigated the antiarrhythmic effects of Ginseng Ginseng (GQS). GQS 60 mg/kg i.v. had a protective effect against chloroform-induced ventricular fibrillation in mice, and the incidence of ventricular fibrillation was reduced by 73.4% compared to the control group. GQS 80 mg/kg i.v has obvious preventive and therapeutic effects on strontium arrhythmia induced by strontium chloride. GQS 80 mg/kg i.v can significantly increase the threshold dose of ouabain-induced ventricular tachycardia, ventricular tachycardia, ventricular fibrillation and arrest in guinea pigs. GQS 60mg/kg, 80mg/kg i.v, have significant antagonistic effect on rat myocardial ischemia and arrhythmia induced by the posterior pituitary preparation. GQS had no effect on aconitine-induced arrhythmias in rats.