论文部分内容阅读
治感佳胶囊是一种由山芝麻、葫芦茶、三叉苦和对乙酰氨基酚等中西药组成的抗感冒复方制剂,用于伤风引起的头痛发热等。本工作以镇痛、解热、抑菌为指标,对该药进行了药理作用观察,结果报告如下。实验材料 1.金黄色葡萄球菌,绿脓杆菌,乙型链球菌,伤寒、副伤寒甲、乙菌苗(简称“三联菌苗”)。 2.NIH种小白鼠,新西兰家兔。方法和结果 1.镇痛作用:采用醋酸扭体法。取18～22g NIH种小白鼠30只,雌雄兼有,随机分为2组。第一组按330mg/kg剂量治感佳药液灌胃,第二组为生理盐水空白对照组,(同等体积生理盐水0.5ml/20g灌胃)。给药1小时后,所有动物腹腔注射0.7％冰醋酸0.1ml/10g,记录30分钟内小鼠出现的扭体反应次数,结果见表1。
Zhiganjia capsule is a kind of anti-cold compound preparation consisting of Chinese sesame seeds, gourd tea, trigeminal bitter and acetaminophen, etc. It is used for headache and fever caused by colds. In this work, analgesic, antipyretic and antibacterial agents were used as indicators to observe the pharmacological effects of the drug. The results are reported below. Experimental Materials 1. Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pyogenes, typhoid, paratyphoid A, and B vaccine (referred to as “triple bacterin”). 2. NIH mice, New Zealand rabbits. Methods and Results 1. Analgesic effect: The acetic acid writhing method was used. Thirty-six 18- to 22-g NIH mice were used, both male and female, and randomly divided into 2 groups. The first group was treated with a 330 mg/kg dose of ganjing liquid, and the second group was saline control group (the same volume of saline 0.5ml/20g gavage). One hour after the administration, all animals were intraperitoneally injected with 0.1% glacial acetic acid 0.1 ml/10 g, and the writhing response times of mice within 30 minutes were recorded. The results are shown in Table 1.