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目的 :探讨双黄连注射液在生物体内抗细菌内毒素的效果。方法 :观察双黄连注射液对内毒素休克小鼠的生存时间及对内毒素所致大鼠肝、肺、肾等病理改变的影响。用鲎试剂法测定双黄连注射液所致大鼠和人体血浆内毒素的含量变化。结果 :双黄连注射液可明显降低动物和人体血浆内毒素含量 ,延长内毒素休克小鼠的平均生存时间 ,对内毒素所致大鼠的肝、肺、肾等损害具有保护作用。结论 :双黄连注射液在生物体内具有显著的抗内毒素作用
Objective: To investigate the effect of Shuanghuanglian injection on bacterial endotoxin in vivo. Methods: To observe the effect of Shuanghuanglian injection on the survival time of endotoxic shock mice and the pathological changes of liver, lung and kidney in rats induced by endotoxin. Determination of Shuanghuanglian injection induced plasma endotoxin levels in rats and human body by using the 鲎 reagent method. Results: Shuanghuanglian injection can significantly reduce the plasma endotoxin content in animals and humans, prolong the mean survival time of endotoxic shock mice and protect the liver, lung and kidney of rats induced by endotoxin. Conclusion: Shuanghuanglian injection has a significant anti-endotoxin effect in vivo