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用放射免疫法测定小儿化脓性脑膜炎、病毒性脑炎、格林一巴利综合征患儿脑脊液β_2—微球蛋白(β_2—m)、白蛋白(AIb)、免疫球蛋白(IgG)共30例。结果以化脑组脑脊液β_2—m、AIb 及IgG 含量明显增高(P<0.01)。当神经系统受累时脑脊液之微球蛋白早期即出现不同程度的升高,且比脑脊液常规及生化变化出现早而恢复正常晚,并随症状的缓解逐渐降至正常。该文介绍了使用放免法测定脑脊液微球蛋白,以提供早期诊断及动态观察治疗后反应依据的临床意义。
Radioimmunoassay was used to detect the levels of β_2-m, albumin (AIb) and immunoglobulin (IgG) in children with purulent meningitis, viral encephalitis and children with Guillain-Barre syndrome example. Results The levels of β_2-m, AIb and IgG in cerebrospinal fluid of EH group were significantly increased (P <0.01). When the nervous system involvement cerebrospinal fluid microglobulin early to varying degrees of elevation, and than the regular and biochemical changes of cerebrospinal fluid returned to normal early, and gradually reduced to normal with the relief of symptoms. This article describes the use of radioimmunoassay of cerebrospinal fluid microglobulin to provide early diagnosis and dynamic observation of the clinical basis of the response after treatment.