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目的 :探讨胃粘膜肥大细胞及其脱颗粒在HP感染中的致病作用。方法 :采用改良甲苯胺兰染色法检测了 14 2例患者胃粘膜中肥大细胞及其脱颗粒情况。结果 :HP阳性者胃粘膜内肥大细胞总数 ( 8.11)及脱颗粒比值 ( 4 7.65 % )均显著高于HP阴性者 ( 4 .2 2 ,3 1.3 2 % ) (P <0 .0 1) ;慢性活动性胃炎及中重度胃炎胃粘膜内肥大细胞总数 ( 8.73 ,8.79)及脱颗粒比值 ( 5 7.4 2 % ,5 7.74 % )均显著高于非活动性胃炎 ( 5 .5 4 ,3 5 .0 1% )和轻度胃炎 ( 5 .68,3 5 .5 6% ) (P <0 .0 1～ 0 .0 0 1)。结论 :肥大细胞及其脱颗粒参与了HP的致病过程而导致胃粘膜损伤。
Objective: To investigate the pathogenic role of gastric mucosal mast cells and degranulation in HP infection. Methods: Mast cells in gastric mucosa of 14 2 patients and their degranulation were detected by modified toluidine blue staining. Results: The number of mast cells (8.11) and degranulation ratio (4 7.65%) in gastric mucosa of HP positive group were significantly higher than those of HP negative group (4.22, 32.32%) (P <0.01). The total number of mast cells (8.73, 8.79) and degranulation ratio (5 7.42%, 5 7.74%) in chronic active gastritis and moderate-severe gastritis were significantly higher than those in inactive gastritis (5.54,35). 0 1%) and mild gastritis (5.68,35.56%) (P <0.01 ~ 0.0101). Conclusion: Mast cells and their degranulation are involved in the pathogenesis of HP and cause gastric mucosal injury.