本文利用自制常压缺氧舱复制缺氧性肺动脉高压模型。实验用雄性Wistar大鼠,分别缺氧1、2及4周。结果表明缺氧1周大鼠Pap、Rvp即明显升高,2周时达高峰并持续高水平,同时大鼠右心重量明显增加。用放射配基结合法观察了缺氧大鼠肺组织β、β_2及α_2受体的动态变化,发现缺氧1周β受体数目略升高,2及4周明显下降,β_2受体与β受体变化规律一致,β_2/β、β_2/β_1比例明显降低,说明缺氧时β受体的下降主要是 In this paper, hypoxia-induced hypoxia model home-made hypoxia replication model. Male Wistar rats were hypoxic for 1, 2 and 4 weeks respectively. The results showed that at 1 week of hypoxia, the levels of Pap, Rvp increased significantly, reaching the peak at 2 weeks and continuing to high level, meanwhile, the right heart weight of rats increased significantly. The dynamic changes of β, β 2 and α 2 receptors in lung tissue were observed by radioligand binding assay. The numbers of β receptors in lung tissue slightly increased at 1 week and decreased obviously at 2 and 4 weeks, The changes of the receptor were consistent, the ratio of β_2 / β and β_2 / β_1 decreased significantly, indicating that the decline of β receptor in hypoxia was mainly