论文部分内容阅读
目的:验证和比较中性粒细胞与淋巴细胞比值(N/L比值)、红细胞分布宽度(RDW)和血小板计数(PLT)这3种血细胞参数对乙型肝炎肝硬化(LC)的预测价值。方法:选取慢性乙型肝炎(CHB)患者152例、LC患者177例,采用全自动血细胞分析仪对所有对象进行血常规检测。结果:LC患者N/L比值和RDW均显著高于CHB;而PLT显著降低。ROC曲线分析显示,N/L比值、RDW和PLT诊断LC的曲线下面积分别为0.65,0.72和0.88,前两者之间差异无统计学意义。当3种参数的截点值为1.58,15.05和75.50时,灵敏度分别为0.63,0.70和0.75,特异度分别为0.64,0.64和0.84。结论:3种血细胞参数均对LC具有一定预测价值,其中PLT的准确性最高。
Objective: To verify and compare the predictive value of three kinds of blood cell parameters such as neutrophil to lymphocyte ratio (N / L ratio), erythrocyte distribution width (RDW) and platelet count (PLT) in the diagnosis of hepatitis B cirrhosis (LC). Methods: 152 patients with chronic hepatitis B (CHB) and 177 patients with LC were enrolled in this study. Blood samples were collected from all patients by automatic hematology analyzer. Results: The N / L ratio and RDW in LC patients were significantly higher than those in CHB; PLT was significantly decreased. ROC curve analysis showed that the areas under the curves of N / L ratio, RDW and PLT were 0.65,0.72 and 0.88, respectively. There was no significant difference between the two. The sensitivities were 0.63, 0.70 and 0.75 respectively when the cut-off values of the three parameters were 1.58, 15.05 and 75.50, and the specificity were 0.64, 0.64 and 0.84, respectively. CONCLUSION: All three kinds of blood cell parameters have a certain predictive value for LC, of which PLT has the highest accuracy.