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目的探讨单用亚甲蓝示踪剂在乳腺癌前哨淋巴结活检术(SLNB)中的临床应用效果。方法回顾性分析2010年7月至2012年6月年本科室收治的47例临床腋窝淋巴结阴性乳腺癌采用单用亚甲蓝示踪剂行 SLNB及腋窝淋巴结清扫术(ALND)的临床资料。结果47例患者中46例成功施行 SLNB,成功率97.8%；在前30例的学习曲线阶段,30例中有6例前哨淋巴结有癌转移,转移率20%；与 ALND术后结果比较,SLNB准确率100%,假阴性率0%。与行 ALND患者比较,行 SLNB患者术后患肢淋巴水肿、肩部不适、肩关节活动障碍等不良事件发生率明显降低。结论在规范操作的前提下,单用亚甲蓝示踪剂行乳腺癌 SL-NB简单可行、安全有效、可获得良好的成功率和准确率。“,”Obj ective]To explore the clinical efficacy of methylene blue as single tracer for sentinel lymph node biopsy(SLNB)in breast cancer.[Methods]Clinical data of 47 patients with clinical axillary lymph node-negative breast cancer undergoing SLNB and axillary lymph node dissection(ALND)in our department from July 2010 to June 2012 were analyzed retrospectively.[Results]Among 47 patients,46 patients underwent SLNB successfully,and the success rate was 97.8%.During the learning curve period of 30 patients,6 pa-tients had sentinel lymph node metastases,and the metastasis rate was 20%.Compared with the outcomes of ALND,the accuracy and false negative rate of SLNB were 100% and 0%,respectively.Compared with pa-tients undergoing ALND,the incidence rates of lymphedema of diseased limbs,shoulder discomfort,shoulder joint movement disorder and so on in patients undergoing SLNB were obviously reduced.[Conclusion]Based on the standard operation,methylene blue as single tracer for SLNB in breast cancer is simple,feasible,safe and effective,and can obtain good success rate and accuracy rate.