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为探讨不同类型不同严重程度慢性肝炎对氯氮平及去甲氯氮平血浓度的影响,对92例合并慢性肝炎(分慢性迁延型肝炎、慢性活动型肝炎两型及轻度、中度、重度三种严重程度)和40例无肝脏疾病的精神分裂症病人,于服药后2周、6周末检测氯氮平血药浓度。结果显示,中度、重度慢性肝炎及慢性活动性肝炎与对照组均有显著差异,轻度慢性肝炎及慢性迁延型肝炎与对照组比较均无显著差异,而慢性肝炎各型及各严重程度与对照组去甲氯氮平浓度均无显著差异。
To investigate the different types of chronic hepatitis with different severity of clozapine and norclozapine blood concentration, 92 patients with chronic hepatitis (chronic chronic hepatitis, chronic active hepatitis type and mild, moderate, Severe three kinds of severity) and 40 patients with schizophrenia without liver disease, taking clozapine plasma concentrations at 2 weeks and 6 weeks after taking the medicine. The results showed that moderate and severe chronic hepatitis and chronic active hepatitis were significantly different from the control group, mild chronic hepatitis and chronic persistent hepatitis compared with the control group no significant difference, and various types of chronic hepatitis and the severity and There was no significant difference in the concentrations of norczolam in the control group.