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目的探讨盐酸吡柔比星术前介入化疗治疗局部晚期乳腺癌的临床疗效与作用。方法选取我院2010-2013年期间行酸吡柔比星术前介入化疗治疗晚期乳腺癌患者118例进行回顾性分析,并依据治疗方式将患者分为两组,即对照组(n=58)和观察组(n=60),对照组术前给予全身静脉化疗,观察组术前给予盐酸吡柔比星介入化疗,观察两组患者术前的临床变化情况,比较两组患者的临床化疗效果,并对两组患者的生存质量进行分析和评价。结果从临床疗效及临床治疗的稳定性来看,观察组患者的治疗效果明显优于对照组,两组差异显著,有统计学(P<0.05);观察组在生存生活质量功能的各方面评估均高于对照组,两组患者生存生活质量差异明显,有统计学意义(P<0.05)。结论盐酸吡柔比星术前介入化疗治疗局部晚期乳腺癌,近期疗效满意,提高手术切除成功率,能最大限度减少不良反应,提高患者生活质量。盐酸吡柔比星术前介入化疗治疗局部晚期乳腺癌达到了很好的辅助治疗的效果,能够有效地提高手术治疗的效果,且副作用较少,是一种比较理想的术前介入治疗方式。
Objective To investigate the clinical effect and effect of preoperative chemotherapy with pirarubicin in the treatment of locally advanced breast cancer. Methods A retrospective analysis was performed on 118 patients with advanced breast cancer treated with preoperative chemotherapy with pirarubicin between 2010 and 2013 in our hospital. Patients were divided into two groups according to the mode of treatment: control group (n = 58) And observation group (n = 60). The control group was given intravenous chemotherapy before surgery. The observation group was given pirarubicin hydrochloride before interventional chemotherapy, and the clinical changes of the two groups were observed before and after treatment. The clinical effects of chemotherapy were compared between the two groups , And the quality of life of two groups of patients were analyzed and evaluated. Results From the clinical curative effect and the stability of clinical treatment, the treatment effect of the observation group was obviously better than that of the control group, with significant difference between the two groups (P <0.05); the observation group evaluated in all aspects of the quality of life and quality of life Were higher than the control group, the two groups of patients with significant differences in the quality of life, with statistical significance (P <0.05). Conclusion Pramrubine hydrochloride preoperative intervention chemotherapy for locally advanced breast cancer, the recent satisfactory results, improve the success rate of surgical resection, minimizing adverse reactions, improve patient quality of life. Pirarubicin hydrochloride preoperative interventional chemotherapy for locally advanced breast cancer has achieved a good effect of adjuvant therapy, which can effectively improve the effect of surgical treatment, and fewer side effects, is an ideal preoperative interventional treatment.