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采用听生理学、前庭功能试验及电镜观察,研究多粘菌素B鼓室内注射的耳蜗和前庭毒性,结果表明:(1)多粘菌素B可由圆窗膜进入内耳引起耳蜗和前庭损害,从而导致感觉神经性耳聋和眩晕;(2)其损害程度与多粘菌素B使用浓度及时间成正比。
Auditory physiology, vestibular function tests, and electron microscopy observations were performed to investigate the cochlear and vestibular toxicity of polymyxin B in the tympanic cavity. The results showed that: (1) Polymyxin B can enter the inner ear from the round window membrane and cause damage to the cochlea and vestibule. Causes sensory nerve deafness and dizziness; (2) The degree of damage is proportional to the use concentration and time of polymyxin B.