论文部分内容阅读
幽门螺杆菌(HP)主要毒力因子之一是中性粒细胞激活蛋白(HP-NAP)。HP-NAP由napA基因编码,相对分子质量150×10~3,对中性粒细胞、单核细胞有趋化作用,导致中性粒细胞浸润胃黏膜,并诱导中性粒细胞NADPH氧化酶激活,产生活性氧中间产物(ROD),引起黏膜炎症和组织损伤。HP-NAP抗原性强,大多数HP感染患者产生NAP抗体,用HP-NAP免疫小鼠能保护机体抵抗HP的感染,保护率80%,表明HP-NAP可作为HP多成分疫苗的候选抗原。现就幽门螺杆菌NAP蛋白在致病和免疫中的作用研究进展作一综述。
One of the major virulence factors of Helicobacter pylori (HP) is neutrophil activating protein (HP-NAP). HP-NAP, encoded by the napA gene, has a molecular weight of 150 × 10 ~ 3 and chemotaxis to neutrophils and monocytes, leading to infiltration of neutrophils into the gastric mucosa and induction of neutrophil NADPH oxidase activation , Produce reactive oxygen intermediates (RODs), cause mucosal inflammation and tissue damage. HP-NAP has strong antigenicity. Most HP infected patients produce NAP antibody. HP-NAP immunized mice can protect the body against HP infection with a protection rate of 80%, indicating that HP-NAP can be used as candidate antigen for HP multi-component vaccine. The progress on the role of Helicobacter pylori NAP in pathogenesis and immunity is reviewed.