论文部分内容阅读
目的探讨主动免疫联合孕激素治疗封闭抗体阴性所致复发性流产(RSA)的疗效。方法将150例RSA患者按随机数字表法分为两组,每组75例,对照组采用淋巴细胞主动免疫治疗,实验组采用主动免疫联合孕激素治疗,比较两组妊娠成功率和治疗前后血清白细胞介素(IL)-6、IL-10、肿瘤坏死因子-α(TNF-α)、γ-干扰素(IFN-γ)水平变化情况。结果实验组妊娠成功率高于对照组(P<0.05);两组封闭抗体阳性和阴性患者妊娠成功率比较差异均无统计学意义(P>0.05);与治疗前比较,两组血清IL-6、IL-10水平升高,TNF-α、IFN-γ水平降低,治疗后实验组血清IL-6、IL-10水平高于对照组,血清TNF-α、IFN-γ水平低于对照组,差异均有统计学意义(P<0.05,P<0.01)。结论主动免疫联合孕激素治疗封闭抗体阴性所致RSA可有效提高妊娠成功率,且经济方便,有推广应用价值。
Objective To investigate the efficacy of active immunization combined with progestin in the treatment of recurrent spontaneous abortion (RSA) caused by negative antibody. Methods 150 cases of RSA patients were divided into two groups according to random number table method, 75 cases in each group. The control group was treated by active immunization of lymphocytes. The experimental group was treated by active immunization combined with progestin. The success rate of pregnancy and serum before and after treatment IL-6, IL-10, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) Results The success rate of pregnancy in experimental group was higher than that in control group (P <0.05). There was no significant difference in pregnancy success rate between two groups of positive antibody and negative antibody (P> 0.05). Compared with before treatment, the serum IL- 6, IL-10 levels, TNF-α, IFN-γ levels decreased after treatment, the experimental group serum IL-6, IL-10 levels were higher than the control group, serum TNF-α, IFN- , The differences were statistically significant (P <0.05, P <0.01). Conclusion Active immunization combined with progestin treatment of RSA by blocking antibody negative can effectively improve the success rate of pregnancy, and the economy is convenient, and has the value of popularization and application.