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采用１∶１配比病例对照研究方法，将１１０例临床确认为铜绿假单胞菌（ＰＡ）下呼吸道医院感染病例，同时配以感染对照和非感染对照进行分析，探讨了ＰＡ下呼吸道医院感染的危险因素。多因素条件Ｌｏｇｉｓｔｉｃ回归分析表明：病例与非感染对照比较，显示病情重、气管切开、机械通气、雾化吸入、３种以上抗生素疗程≥２周、慢性阻塞性肺部疾病（ＣＯＰＤ）、重症监护和纤支镜检查为ＰＡ下呼吸道医院感染独立的危险因素；病例与感染对照比较，则气管切开、机械通气、雾化吸入、重症监护和纤支镜检查为ＰＡ下呼吸道医院感染独立的危险因素。持续吸氧对下呼吸道感染具有保护作用。单因素分析还发现原先有肺部感染和插胃管与ＰＡ下呼吸道医院感染有关（Ｐ＜０．０５）。
A case-control study with a ratio of 1: 1 was used to identify 110 clinically confirmed cases of nosocomial infections of lower respiratory tract of Pseudomonas aeruginosa (PA), together with infected controls and non-infected controls, and to explore the relationship between lower respiratory tract nosocomial infections Risk factors. Multivariate conditional Logistic regression analysis showed that patients with severe disease, tracheotomy, mechanical ventilation, inhalation of inhalation, three or more antibiotics ≥2 weeks, chronic obstructive pulmonary disease (COPD), severe disease Monitoring and bronchoscopy were independent risk factors for lower respiratory tract nosocomial infections in PA patients. Tracheotomy, mechanical ventilation, nebulization, intensive care, and bronchofibroscopy were used as PA lower respiratory tract infections in patients independent of infection Risk factors. Continuous oxygen inhalation has a protective effect on lower respiratory tract infection. Univariate analysis also found that the original pulmonary infection and gastric intubation with PA lower respiratory tract infection (P <0.05).