近年来,肿瘤发病率和死亡率呈上升趋势~([1])。肿瘤的发生、发展是一个多因素、多步骤的变化过程。目前,其分子机制仍未研究透彻。Rab23属于小GTP酶,是Ras致癌基因家族的一名成员,位于染色体6p12.1,最早是由Olkkonen等~([2])1994年从小鼠脑部分离得到。Rab23能够调节真核细胞的囊泡运输以及蛋白转运,其基因突变引起的功能缺失会导致一些先天性疾病的发生,如Carpenter综合征和史蒂文森-约翰逊综合 In recent years, the incidence of cancer and mortality are on the rise ~ ([1]). Tumor occurrence and development is a multi-factor, multi-step change process. At present, its molecular mechanism has not been studied thoroughly. Rab23 is a small GTPase and is a member of Ras oncogene family. It is located on chromosome 6p12.1 and was first isolated from the brain of mice by Olkkonen et al. ([2]) in 1994. Rab23 regulates vesicular trafficking and protein transport in eukaryotic cells, and loss of function due to mutations in its genome can lead to the development of several congenital diseases such as Carpenter’s syndrome and Stevenson-Johnson syndrome