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目的:研究应用介入方法治疗葡萄胎的临床疗效,同时探讨介入成为一种新的治疗葡萄胎方法的可行性。方法:应用Seldinger技术向葡萄胎的毛细血管床内缓慢灌注大剂量5-FU后,用48%超液化碘油栓塞毛细血管床、同时配合明胶海绵条栓塞双侧子宫动脉主干。结果:共治疗36例葡萄胎患者,介入治疗90天后,所有患者的HCG值均稳定在正常范围内。其中,27例患者在治疗3个月后葡萄胎瘤体消失,9例患者在治疗3个月后葡萄胎瘤体平均体积缩小到4.58cm3,与介入治疗前相比,体积较缩小了97.52%;随访2年,25例患者疗效显著,占总病例的69.4%;11例患者有效,占总病例的30.6%;经介入治疗的本组病例均有效。结论:介入治疗葡萄胎的临床疗效确定,是一种创伤小、疗效肯定的新方法,具有很好的临床应用价值。
Objective: To study the clinical efficacy of interventional therapy for hydatidiform mole and to explore the feasibility of intervention as a new hydatidiform mole treatment. Methods: The capillary bed of hydatidiform mole was slowly infused with 5-FU with Seldinger technique. The capillary bed was embolized with 48% hyperlipemic lipiodol and the main artery of bilateral uterine artery was embolized with gelatin sponge. Results: A total of 36 patients with hydatidiform mole were treated. After 90 days interventional treatment, the HCG values of all the patients were stable within the normal range. Among them, 27 patients died of hydatidoma after 3 months of treatment, and the average volume of hydatidiform mole was reduced to 4.58cm3 in 9 patients after 3 months of treatment. Compared with that before intervention, the volume of tumor decreased 97.52% ; 2 years follow-up, 25 patients were significantly effective, accounting for 69.4% of the total cases; 11 patients were effective, accounting for 30.6% of the total cases; interventional treatment of this group of patients were effective. Conclusion: The clinical efficacy of interventional treatment of hydatidiform moles is confirmed, which is a new method with small trauma and definite effect, which has a good clinical value.