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目的 :评价ⅠCTP诊断肺癌早期骨转移的效能。方法 :用放免法测定 86例肺癌患者和 3 0例健康者血清ⅠCTP浓度 ,并随访半年至 2年。结果 :骨转移者血清ⅠCTP ( 7.2 4± 3 .0 9μg/L )明显高于无骨转移 ( 4 .19±2 .4 9μg/L ,P <0 .0 0 1)和健康者 ( 3 .83± 1.0 7μg/L ,P <0 .0 0 1)。ICTP、核素骨显像诊断肺癌骨转移的准确性(ROC曲线下的面积 )、灵敏度和特异度分别为 :0 .82、0 .74 (P <0 .0 5 ) ;86%、80 % ;81%、72 %。Logistic回归分析 ,ⅠCTP、核素骨显像与骨转移的相关系数分别为 :r=0 .3 8,P <0 .0 0 5 ;r=0 .2 5 ,P <0 .0 5。随访发现ⅠCTP随骨转移的范围增多而增高。结论 :ⅠCTP是诊断肺癌早期骨转移的良好标志物 ,有助于随访和监测肺癌骨转移 ,能早于骨显像发现骨转移。若ⅠCTP低于正常值则骨转移的可能性相当低 ,高于正常值则有骨转移的可能
Objective: To evaluate the efficacy of ICTP in the diagnosis of early bone metastasis in lung cancer. METHODS: Serum ICTP concentrations in 86 lung cancer patients and 30 healthy individuals were determined by radioimmunoassay and followed up for six to two years. Results: Serum ICTP (7.2 4±3.09μg/L) was significantly higher in patients with bone metastases than in those without bone metastases (4.19±2.99μg/L, P <0.01) and healthy subjects (3. 83 ± 1.0 7 μg/L, P <0.01. The accuracy of ICTP and radionuclide bone imaging in the diagnosis of bone metastases from lung cancer (area under the ROC curve), sensitivity, and specificity were 0.82, 0.74 (P < 0.05), 86%, and 80%, respectively. 81%, 72%. Logistic regression analysis showed that the correlation coefficients of ICTP, radionuclide bone imaging and bone metastasis were: r = 0.38, P <0.05, r = 0.25, P <0. Follow-up found that ICTP increased with the scope of bone metastases. Conclusion : ICTP is a good marker for diagnosing early bone metastasis of lung cancer, which is helpful for the follow-up and monitoring of bone metastasis of lung cancer. It can be found earlier than bone imaging. If the ICTP is lower than normal, the probability of bone metastases is rather low. Above the normal value, there is the possibility of bone metastasis.