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药物的溶解度直接影响药物在体内的吸收和生物利用度,复方配伍不仅会影响有效成分溶出率的变化,而且可反映复方协同增效的优势。中药复方的物质基础不仅仅是每味中药有效成分的总和,在提取、溶出、吸收、分布、代谢、排泄等各个环节都伴有成分间的相互作用,都可能有增溶作用的存在[1]。有鉴于此,如何结合中医药理论,阐明中药复方配伍增溶的物质基础与作用机制势在必行。由于中药复方成分复杂,存在成分间的相互作用,不但可以产生
The solubility of the drug directly affects the absorption and bioavailability of the drug in the body. The compound compatibility will not only affect the change of the dissolution rate of the active ingredient, but also reflect the advantages of the compound synergies. The material basis of traditional Chinese medicine compound is not only the sum of the active ingredients of each Chinese herb, but also the interaction between ingredients in extraction, dissolution, absorption, distribution, metabolism, and excretion, all of which may have the effect of solubilization [1 ]. In view of this, it is imperative to clarify the material basis and the mechanism of action of the compatibility and solubilization of traditional Chinese medicine based on the theory of traditional Chinese medicine. Due to the complex composition of Chinese herbal medicines, there are interactions between ingredients that can not only produce