我们曾报道一种抗人血小板单克隆抗体(McAb)HIP_2能识别GPⅡ_b(M.W.140KD),并有明显刺激血小板引起聚集和释放的功能.并提出基于其对血小板功能的不同影响,可将抗血小板抗体分为刺激型、抑制型和无作用型三种。 最近发现HIP_2 McAb有明显刺激多系造血祖细胞增殖的作用。用半固体培养集落形成技术研究发现,在CFU-E体系中HIP_2有同等或优于红细胞生成刺激素(EPO)的作用。CFU-E集落形成 We have reported that an anti-human platelet monoclonal antibody (HIP_2) recognizes GPⅡ_b (MW140KD) and significantly stimulates the aggregation and release of platelets, and proposes that based on their different effects on platelet function, antiplatelet Antibody is divided into stimulating, inhibitory and non-acting three. Recently, it was found that HIP_2 McAb significantly stimulated the proliferation of multi-lineage hematopoietic progenitor cells. Using semi-solid culture colony formation technique, we found that HIP_2 has the same or better effect than erythropoietic stimulating hormone (EPO) in CFU-E system. CFU-E colony formation