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目的 了解甲萘威的男性生殖毒性。方法 选择某农药厂接触甲萘威生产的男工31名为暴露组;该厂行政区男性员工4 6名为内对照组;某疾病预防控制中心男性员工2 2名为外对照组。对各组环境空气中甲萘威及其相关气体异氰酸甲酯(MIC)、氨气及总酚进行连续3d的监测;选暴露组及外对照组各3人进行个体采样并测定其皮肤污染量;收集各组人群的精液,进行精液质量、精子的形态学评价,用计算机辅助精子分析(CASA)系统分析精子的运动能力。结果 暴露组作业环境空气中甲萘威的几何平均浓度(G)为5 2 .4 1mg/m3 、总酚为0 .0 8mg/m3 ,均高于内、外对照组,差异有统计学意义(P <0 .0 5或P <0 .0 1)。暴露组男工个体采样甲萘威浓度(G)为7.38mg/m3 ,皮肤的污染量(G)为86 2 .4 7mg/m2 ;外对照组均未检出。暴露组男工精子直线运动速度[VSL ,(2 6 .2 9±7.84 )μm/s]、鞭打频率[BCF ,(3.99±1.5 5 )Hz]、直线性(LIN ,39.89%±6 .0 0 % )、前向性(STR ,71.5 1%±11.2 2 % )均低于内、外对照组,精液黏稠度、精子活动度异常率及精子总畸形发生率均高于外对照组,精液量[(2 .39±1.4 4 )ml]、精子活动度[(1.77±0 .6 1)级]低于外对照组,差异均有统计学意义(P <0 .0 5 )。结论 甲萘威职业暴露对男工精子和精液质量有一定影响
Objective To understand the male reproductive toxicity of carbaryl. Methods Thirty-one male workers who were exposed to carbaryl in a pesticide factory were selected as the exposure group, 46 male employees in the administrative region of the factory were treated as internal control group, and 22 were males in a CDC. Carbendazim and its related gases, methyl isocyanurate (MIC), ammonia and total phenol in the ambient air of each group were continuously monitored for 3 days. Three individuals in the exposed group and the external control group were sampled and their skin The amount of pollution was collected. The semen of each group was collected and the sperm quality and sperm morphology were evaluated. The sperm motility was analyzed by computer assisted sperm analysis (CASA) system. Results The geometric mean concentration (A) of carbaryl in the ambient air of the exposed group was 52.4 mg / m3 and the total phenol was 0.08 mg / m3, both of which were higher than those of the control group (P <0.05 or P <0.01). In the exposed group, the concentration of carbaryl (7.38mg / m3) and the amount of skin contamination (G) of 86.24.7mg / m2 for the male workers were not detected in the external control group. Linear velocity (LIN, 39.89% ± 6. 0, BCF, (3.99 ± 1.5 5) Hz], linear velocity of male sperm in the exposed group [VSL (26.29 ± 7.84) μm / s] 0%), forward (STR, 71.5 1% ± 11.2 2%) were lower than the control group, the semen viscosity, the abnormal rate of sperm motility and the incidence of sperm deformity were higher than the control group, (2.39 ± 1.4 4) ml and sperm motility (1.77 ± 0.61) were lower than those in the control group (P <0.05). Conclusion Carbarone occupational exposure has certain influence on the quality of male workers’ sperm and semen