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目的了解东莞市婴儿接种乙肝疫苗的免疫效果,评价防治效果,为制定防治对策提供科学依据。方法采用分阶段随机抽样方法,抽取东莞市五个镇981名一周岁内按国家免疫规划程序接种完3针5μg乙肝疫苗的婴儿作为监测对象,进行乙肝标志物血清学监测。结果981名监测对象中,抗-HBs阳转率达97.04%(952/981);HBsAg携带率为0.41%(4/981);母婴传播阻断保护率为93.83%;母亲HBsAg阴性婴儿的抗-HBs阳转率和GMT均高于母亲HBsAg阳性的婴儿,两者差异有显著性意义;而第1针及时接种与否、性别和出生体重间抗-HBs阳转率差异无统计学意义。结论东莞市婴儿按国家免疫规划程序接种完3针5μg乙肝疫苗抗-HBs阳转率达到较高水平,母亲HBsAg携带状况是婴儿乙肝疫苗抗-HBs阳转率和抗体滴度的主要影响因素之一。
Objective To understand the immune effect of hepatitis B vaccination in infants in Dongguan City, evaluate the effect of prevention and treatment, and provide a scientific basis for the development of control strategies. Methods A total of 981 infants who were vaccinated with 3 doses of 5 μg hepatitis B vaccine within 1 year of age in five towns of Dongguan City were enrolled in this study. The serological surveillance of hepatitis B markers was performed. Results Among 981 subjects, the positive rate of anti-HBs was 97.04% (952/981); the rate of HBsAg carrier was 0.41% (4/981); the rate of maternal and child transmission interruption was 93.83%; the rate of HBsAg negative infants The anti-HBs positive rate and GMT were higher than those of mothers with HBsAg-positive infants, and there was significant difference between them. However, there was no significant difference in the positive rate of anti-HBs between the first vaccination and the first vaccination . Conclusion The positive rate of anti-HBs immunization of 3-dose 5μg Hepatitis B vaccine inoculated in Dongguan City reached a high level according to the national immunization schedule. The carrier status of HBsAg in mothers was the main influencing factor of anti-HBs positive rate and antibody titers in infants with hepatitis B vaccine one.