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血清肌红蛋白(MB)是一种低分子量的蛋白质,仅位于横纹肌和心肌,MB漏出的增加而进入血循环必然是肌细胞损害的特异性指征.本文作者用放射免疫法测定了85例具有肌肉症状患者的血清MB,其中男44例,女41例,年龄20-80岁.测定结果发现,在肌原性肌病组,MB升高最显著,28例肌原性肌病患者中,MB升高者26例(93%),而肌酸磷酸激酶(CPK)升高者只有17例(61%),多发性肌炎患者的MB值最高,11例多发性肌炎患者MB均升高,而CPK升高者只有7例.对于7例多发性肌炎患者在6-33个月期间,多次测定MB,发现MB和临床过程之间有明显的关系.在激素治疗开始后数周之内,MB下降,比临床症状的改善稍早或平行;病情恶化者,MB迅速升高.在28例重症肌无力患者中,MB升高者15例,CPK升高者2例.在MB升高的15例中,6例轻度全身性肌无力,9例严重的全身性肌无力;15例中
Serum Myoglobin (MB), a low-molecular-weight protein located only in the striated muscle and myocardium, is a specific indicator of myocyte damage due to increased MB leakage and entry into the blood circulation.The authors used radioimmunoassay to determine the presence of 85 Serum MB in patients with muscular symptoms, including 44 males and 41 females, aged 20-80 years.The results showed that, in myogenic myopathy group, MB increased the most significant, 28 cases of myogenic myopathy patients, MB elevated in 26 cases (93%), while elevated creatine phosphokinase (CPK) in only 17 cases (61%), MB in patients with polymyositis was the highest MB in 11 patients with myositis High, and elevated CPK only 7 cases.For 7 cases of polymyositis patients in the 6-33 months, repeated determination of MB and found that MB and the clinical course of a clear relationship between the number of hormone therapy after the start MB decreased in a week, slightly earlier than or parallel to the improvement of clinical symptoms; MB increased rapidly in 28 patients with myasthenia gravis, elevated MB in 15 and elevated CPK in 2. In Of the 15 patients with elevated MB, 6 had mild generalized muscular weakness and 9 had severe generalized muscular weakness; in 15